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Who we are

ProteinQure is a computational platform for protein drug discovery. We partner with pharma to deliver experimentally validated novel chemical matter. We combine molecular simulations, machine learning and high performance computing algorithms to perform structure-based drug design. These physics based methods make us less dependent on large data sets. We have 3 large commercial partnerships (see our partnering page).

Our applications

Our partnerships involve wetlab validation and areas where data availability is often a challenge (GPCR and intracellular targets, non-natural amino acids etc.). We focus on novel peptides optimized for binding, specificity and other pharmacokinetic properties. In addition we engineer proteins to incorporate multiple binding domains. Our platform allows our partners to leverage their proprietary wetlab technologies to interrogate biology in new ways.

ibm quantum computer

De-novo hits

We design hits which are novel chemical entities. Our platform is designed to iterate with experimental results to save you time and money.

mathematics whiteboard

Property optimization

We perform iterative optimization of therapeutic leads to preserve properties like binding affinity, selectivity, stability and solubility. This multi-parameter optimization requires a search over vast areas of sequence space.

multiparameter optimization landscape

Library design

We design large protein libraries (for display methods) where every member incorporates computationally designed motifs.


Despite their inherent advantages, it is very difficult to design protein based therapeutics. Computational tools have been previously held back because of proteins' larger size and the lack of available structural data. We leverage physics based methods and novel machine learning algorithms to overcome these challenges.

protein therapeutics scale


Proteins can target a wider range of binding sites compared to small molecules. We work on difficult targets including GPCRs and intracellular targets.


Our therapeutics are engineered to be highly specific. Reducing unintended off target effects.


We engineer therapeutics with multiple binding epitopes. Helping to optimize new modalities.


Please click on the images below to view or download the files.

our team


our advisors

The combination of designed peptide libraries, based on ProteinQure’s computational methods, with our advanced capabilities in display technologies will help us harness the potential of this therapeutic class.

Tristan Vaughan, VP of Antibody Discovery & Protein Engineering, AstraZeneca

Our Address

We are located in downtown Toronto; one of the fastest growing tech hubs in North America. At the heart of the university and life sciences ecosystems, we benefit from great relationships with the surrounding players in AI and biotech.

ProteinQure - Designing a healthier tomorrow

Interested in learning more? Come talk to us!

Office Address: 119 Spadina Ave Suite 304, Toronto, ON M5V 2L1, Canada



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