ProteinQure uses artificial intelligence and quantum computing for the computational design of protein drugs. Antibodies, peptides, and other protein-based drugs have low toxicity and are capable of targeting a broad range of biological targets outside the scope of traditional small molecule therapeutics. Due to their structural complexity and dynamic flexibility, novel protein-based drugs are challenging to discover. Our software enables the rational design of protein-based drugs via atomistic simulations of the protein folding and binding process.
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Welcome to computational protein drug design.
We are unlocking the potential of protein based therapeutics
We design small peptide based therapeutics (including cyclic peptides).
Exploring protein structures
without data or known crystal structures.
Quantum computing, artificial intelligence and molecular dynamics simulations.
The first step to designing large protein-based drugs beyond the current paradigm.
At ProteinQure, we are building a computational platform for the design of protein therapeutics. Our mission is to help to create a world where drugs are engineered, not just discovered. We partner with industry leaders in drug discovery to generate novel therapeutics outside of the conventional chemical space.
Our technology combines computational biophysical models with statistical and machine learning approaches to enable us to search across vast spaces of protein therapeutics. We build and deploy these computational modules using a scalable computing infrastructure and complement their predictions with results from wet lab experiments.
We enable rational drug discovery by applying new methodologies for structure determination given only protein sequences as input. Experimental data increases our accuracy through the use of integrative models.
From a few target-specific de novo protein binders to high diversity protein libraries, we'll design whatever it takes to make novel protein therapeutics; even if it means scoring trillions of structures.
We perform iterative optimization of therapeutic leads to preserve properties like binding affinity, selectivity, stability and solubility. This multi-parameter optimization requires a search over vast areas of sequence space.
Despite their inherent advantages, it is very difficult to design protein based therapeutics.
ProteinQure is building scalable technologies to aid in structure based protein design.
Proteins can target a wider range of binding sites compared to small molecules.
Structure-based design allows disease treatments with higher specificity and less side effects.
Small peptides are often easier to synthesize and test in the wet lab.
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ENGINEERED NOT DISCOVERED
We are located in downtown Toronto; one of the fastest growing tech hubs in North America. At the heart of the university and life sciences ecosystems, we benefit from great relationships with the surrounding players in AI and biotech.
Interested in learning more? Come talk to us!
Office Address: 119 Spadina Ave Suite 304, Toronto, ON M5V 2L1, Canada
E-Mail: team@proteinqure.com
Web: www.proteinqure.com
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